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FOSAMAX and FOSAMAX PLUS D are FDA approved to reduce the risk of both hip and spine osteoporosis fractures in postmenopausal women.

Presumably due to the effects of Fosamax on increasing bone mineral, small, asymptomatic decreases in serum calcium and phosphate may occur, especially in patients with Paget's disease, in whom the pretreatment rate of bone turnover may be greatly elevated, and in patients receiving glucocorticoids, in whom calcium absorption may be decreased.

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The approval of Fosamax in a dosage form containing seven times the daily dosage strength was based on a clinical study that showed Fosamax 70 mg taken once a week had equivalent effect to Fosamax 10 mg taken once a day in increasing bone mineral density (BMD) in postmenopausal women.

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Siris said that she fears this will be another case in which over-the-top media reports on the inconclusive link between Fosamax and esophageal cancer will scare patients into giving up on a medication that is successfully protecting them from the effects of osteoporosis.

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The bone densitometry test determines the bone mineral density (BMD).

Scott Reuben, fabricated the data used in over twenty pharmaceutical studies published in peer-reviewed medical journals.

In both trials, akathisia occurred most often during the first 3 weeks of treatment, and no incidences resulted in treatment discontinuation.

If the areas of exposed bone in the mouth become infected, or if there is a trauma to the other areas of the mouth as a result of the exposed bone, then the osteonecrosis symptoms may become more noticeable.

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Bisphosphonates interfere with protein prenylation in the osteclasts, which means the production of osteoclasts is reduced, and osteoclast apoptosis, or cell death, is promoted.

Fosamax (alendronate) is also classified as a bisphosphonate and works by slowing down the breakdown of bones.

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What I tell women in their 50s is that having Osteopenia means their bones are different than those of a 25-year-old and I note that there are probably many things about them that differ from when they were 25”.

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Each person responds differently, but, by preventing further decreases in bone density, these medicines reduce the likelihood of broken bones.

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Merck spokesman Ronald Rogers said such musculoskeletal pain has already been recognized for this class of drugs and that such information already is provided to physicians.

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The drug is also licensed to prevent osteoporosis in postmenopausal women.

Patients should be instructed that if they develop symptoms of esophageal disease (such as difficulty or pain upon swallowing, retrosternal pain or new or worsening heartburn) they should stop taking FOSAMAX and consult their physician.

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