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Moreover, in a recently published in vitro screening study, bosutinib was tested against a panel of the most frequent imatinib-resistant Bcr-Abl mutants and was found to have activity against the large majority of them.
In about 5% of all GIST there is a mutation in the related tyrosinkinase PDGFRA.
The majority of patients with marked bilirubin elevations on nilotinib therapy have underlying Gilbert Syndrome.
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These catalysts are very expensive, therefore, their use is unfit for commercial production.
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Complete remission of a metastatic gastrointestinal stromal tumour with the tyrosine kinase inhibitor imatinib (STI 571).
BioDrugScreen: a computational drug design resource for ranking molecules docked to the human proteome.
Imatinib may also be used for other purposes not listed in this medication guide.
Curative therapies are not avail-able, and each MCAD patient should be treated in accordance with his symptoms and complications.
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At 12 months, a higher proportion of patients on dasatinib had achieved MMR (46% with dasatinib vs 28% with imatinib) or CCyR (83% with dasatinib vs 72% with imatinib).
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Patients with metastatic GIST commonly experience relapse if their imatinib therapy is discontinued, as has been shown in the French BFR14 phase III study.
For example, endomyocardial disease has occurred during the course of helminth infections and also in various malignancies associated with marked eosinophilia.
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The average age at diagnosis is 64 years, and this disease is rarely seen in children.
Although there is a high degree of protein binding, in severe toxicity proteins are saturated and most of the drug is found in its free form in the body.
Can chronic myeloid leukaemia in children and adolescents be successfully treated without haematopoietic stem cell transplant?
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Non-adherence to imatinib treatment in patients with gastro-intestinal stromal tumors (GIST): the ADAGIO Study.
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BCR-ABL transcript level of up to 10% by quantitative RT-PCR is considered treatment response and 10% and over is considered failure.
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Evolving concepts in the management of chronic myeloid leukemia: recommendations from an expert panel on behalf of the European LeukemiaNet.
But equally as important, the number of patients who would otherwise be prescribed an ineffective drug and experience adverse effects would decrease, and these patients would then have an opportunity to undertake other approved or experimental therapeutic regimens that might be beneficial.
CML) with resistance, or intolerance to prior therapy.
Attempts to optimize induction and consolidation treatment in acute myeloid leukemia: results of the MRC AML12 trial.
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Un tema importante a tener en cuenta en estos resultados es que el subtipo anemia refractaria con exceso de blastocitos en transformación seguramente representa a pacientes con LMA manifiesta, mientras que anemia refractaria y anemia refractaria con exceso de blastocitos representan SDM.
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